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Michael and Bruno are two half-brothers who could scarcely be more different. Their mother Jane led a carefree life in the jet set – while her sons grew up separately with their respective grandmothers. While the introverted molecular biologist Michael devotes his main attention to genetic research rather than women, Bruno’s "contacts" with the opposite sex have been expressed more in his mind or in brothels.

Finally, however, each one of them meets the love of his life: Michael re-encounters his former school friend Annabelle, with whom he has shared a shy affection since his early childhood. In contrast, Bruno gets to know Christiane at an esoteric holiday camp; here is someone with whom he can finally live out his sexual obsessions. But their happiness appears short-lived – both women become seriously ill. Bruno and Michael face the ultimate decision: do they return to their former, familiar loneliness or accept a new kind of togetherness?